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In one of the world’s leading medical journals, researchers have found that when a patient has less sensitive pupils, it may be the difference between life and death.
In a study, researchers at the University of Sheffield and the University College London found that the number of pupils that a patient’s eyes have narrowed significantly depends on the amount of phenothazine in the eye drug, with less sensitive patients having fewer pupils.
The study, published in the British Medical Journal, found that patients with more sensitive eyes were at a higher risk of developing corneal blindness.
“What we have found is that we have increased the risk of corneatal blindness in those with more sensitivity, but there is no clear cause and effect,” said lead researcher Dr Mark Williams.
“We think that the mechanism is related to the reduction in vision in people with corneas that are less sensitive.”
The team, led by Dr Mark Bailes, discovered that patients had more sensitive pupils when they had more phenothaxine in their eye, but the researchers also found that it was not just the amount that was affected, but how much of that phenothozine had been taken up in the pupil.
“There are some patients who have a very low dose of phenotoxins and it can cause damage to the cornea,” Dr Williams said.
“They may have had the best result if they were only taking 10-20mgs, so it was a dose that they didn’t need.”
Dr Williams said that although the study did not directly test the impact of phenothecin, there were several other factors that could have contributed to the increase in corneocyte damage.
“One of them was that the patients had less retinal pigment to make up the corneocytes.
If you have less retina to make your cornea and your pupil, it can make the corNEs less able to absorb light,” Dr James said.
While there are no drugs currently being tested to treat corneitis, Dr Williams believes there are new treatments that can help.
“These are all the things that are happening in our society now, so we need to find new ways to help those with cornea damage,” he said.